The Bolton side will host Mark Hine's men after the draw for the second round was made.
They beat Coppull 5-0 in last season's final at the LFA County Ground.
Premier Division clubs will join the competition at the second-round stage after a shake-up of the league's cup competitions.
Elsewhere, there's three all Premier division ties - Fulwood Amateurs host Poulton, Turton must travel to Thornton Cleveleys and Wyre Villa head north to face in-form Whitehaven.
There's also a potential east Lancs derby between Rossendale and Haslingden if the latter can get past Croston in a tie yet to be played.
All second-round matches will take place on November 19 or 26.
Astley & Buckshaw v Blackpool Wren Rovers
Burnley United v Lytham Town
Charnock Richard Res v Horwich SMV
Chipping v Burscough Richmond
CMB v Holker Old Boys Res
Eagley v Slyne
Freckleton v Cartmel
Fulwood Amateurs v Poulton
Hurst Green v Walney Island
Kendal Utd v AFC Blackpool Res
Milnthorpe v Lostock St G
Rossendale v Haslingden or Croston
Tempest United v Coppull United
Thornton Cleveleys v Turton
Vickerstown v Askam
Whitehaven v Wyre Villa
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